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NIR-II organic small molecule probe for labeling lymph nodes and guiding tumor imaging.

Authors :
Yuan, Lin
Su, Yingbin
Zhang, Runfeng
Gao, Jie
Yu, Bing
Cong, Hailin
Shen, Youqing
Source :
Talanta. Jan2024:Part 2, Vol. 266, pN.PAG-N.PAG. 1p.
Publication Year :
2024

Abstract

Organic small molecule fluorescent groups have injected new material support into the field of medical imaging due to their unique luminescence mechanism and easy tuning of structure. The great potential of NIR-II window imaging forces us to continuously optimize the structure of organic fluorophores to design better fluorescent molecules for fluorescence imaging-guided surgery. An ideal organic small molecule fluorescent group: it can penetrate into the inside of the organism, clearly present the internal structure and the edge contour of different tissues, so as to perfectly achieve internal imaging and accurately guide external surgery. In vivo, fluorescent groups do not damage normal tissues and organs. However, problems such as low quantum yield and poor biocompatibility greatly limit the clinical transformation of NIR-II fluorescent small molecules. To avoid the shortcomings of NIR-II fluorescent probes as much as possible and better realize image-guided surgery, in this experiment, the biplane donor unit was incorporated into the twisted D-π-A-π-D structure to expand the conjugated structure of the fluorescent group, which not only realized NIR-II emission, but also had high quantum yield and biosafety. [Display omitted] • CED NPs have high quantum yield and biosafety. • CED NPs can clearly show the tumor contour of subcutaneous tumor nude mice. • CED NPs can clearly label the enlarged lymph nodes in nude mice with metastatic tumors. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00399140
Volume :
266
Database :
Academic Search Index
Journal :
Talanta
Publication Type :
Academic Journal
Accession number :
171880024
Full Text :
https://doi.org/10.1016/j.talanta.2023.125123