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Dietary fish and omega-3 polyunsaturated fatty acids intake and cancer survival: A systematic review and meta-analysis.
- Source :
-
Critical Reviews in Food Science & Nutrition . 2023, Vol. 63 Issue 23, p6235-6251. 17p. - Publication Year :
- 2023
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Abstract
- Fish and omega-3 polyunsaturated fatty acids (PUFA) have been suggested to play a role in improving cancer prognosis. However, results from epidemiological studies remain inconsistent. Here we assess the association between dietary fish and/or omega-3 PUFAs intake and cancer prognosis with meta-analysis of observational studies. A systematic search of related publications was performed using PubMed and Web of Science databases. Hazard ratios (HR) and 95% confidence intervals (CI) were extracted and then pooled using a random-effect model. Potential linear and non-linear dose-response relationships were explored using generalized least squares estimation and restricted cubic splines. As a result, 21 cohort studies were included in our analysis. Compared to the lowest category, the highest category of fish intake was associated with a significant lower mortality in patients with ovarian cancer (n = 1, HR = 0.74, 95% CI: 0.57–0.95) and overall cancer (n = 12, HR = 0.87, 95% CI: 0.81–0.94). Marine omega-3 PUFAs intake rather than total omega-3 PUFAs intake showed significant protective effects on survival of overall cancer (n = 8, HR = 0.81, 95% CI: 0.71–0.94), in particular prostate cancer (n = 2, HR = 0.62, 95% CI: 0.46–0.82). Dose-response meta-analysis indicated a nonlinear and a linear relationship between fish intake, as well as marine omega-3 PUFAs intake, and overall cancer survival, respectively. In conclusion, our analysis demonstrated a protective effect of dietary fish and marine omega-3 PUFAs consumption on cancer survival. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10408398
- Volume :
- 63
- Issue :
- 23
- Database :
- Academic Search Index
- Journal :
- Critical Reviews in Food Science & Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 171877386
- Full Text :
- https://doi.org/10.1080/10408398.2022.2029826