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Can oestrogenic activity in air contribute to the overall body burden of endocrine disruptors?
- Source :
-
Environmental Toxicology & Pharmacology . Sep2023, Vol. 102, pN.PAG-N.PAG. 1p. - Publication Year :
- 2023
-
Abstract
- Endocrine disruptors (EDCs) are emerging contaminants that are harmful to health. Human exposure occurs mainly through ingestion or dermal contact, but inhalation could be an additional exposure route; therefore, this study was conducted to evaluate the oestrogenic activity of airborne particulate matter (PM). Outdoor PM was collected for a year in five Italian sites and extracted with organic solvents (four seasonal extracts/site). The oestrogenic activity was assessed using a gene reporter assay (MELN), and the risk to human health through inhalation was quantified using the results. Moreover, extracts were analysed to assess cytotoxicity (WST-1 and LDH assays) on human bronchial cells (BEAS-2B). The extracts induced a significant cytotoxicity and oestrogenic activity. Oestrogenic activity showed a seasonal trend and was correlated with concentrations of benzo(a)pyrene and toxic equivalency factor. Although a low inhalation cancer risk was found, this study confirmed that oestrogenic activity in air could contribute to overall health risks due to EDC exposure. [Display omitted] • Oestrogenic activity of particulate matter (PM) extracts by a gene reporter assay. • Assessment of the inhalation cancer risk due to oestrogenic pollutants on PM. • Significant oestrogenic activity of airborne PM extracts with a seasonal trend. • PM oestrogenic activity correlated with benzo(a)pyrene and toxicity of PAHs. • Airborne PM may contribute to EDC body burden, but oestrogenic cancer risk is low. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13826689
- Volume :
- 102
- Database :
- Academic Search Index
- Journal :
- Environmental Toxicology & Pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 171846201
- Full Text :
- https://doi.org/10.1016/j.etap.2023.104232