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Bir Üniversite Hastanesi Yenidoğan Yoğun Bakım Ünitesi Kan Kültürlerinden İzole Edilen Etkenler ve Antimikrobiyal Duyarlılıklarının İncelenmesi.
- Source :
-
Journal of Current Pediatrics / Guncel Pediatri . Aug2023, Vol. 21 Issue 2, p171-181. 11p. - Publication Year :
- 2023
-
Abstract
- Introduction: Neonatal sepsis is a clinical syndrome characterized by non-specific signs and symptoms caused by various pathogens. The diagnosis is based on a combination of clinical and laboratory findings. Gram-positive and Gram-negative bacteria are the predominant etiologic agents. In our study,we aimed to evaluate the types of microorganisms grown in neonatal blood cultures and antimicrobial susceptibilities of Gram-negative agents. Materials and Methods: We retrospectively analyzed 2566 blood culture results. Samples from blood culture bottles with growth were passaged on blood agar. The growing colonies were identified by MALDİ-TOF MS. Antibiotic susceptibility tests were performed on a fully automated device. The results were evaluated according to EUCAST standards. Results: Growth was detected in 12.1% of the samples. 59.5% of the patients with growth were male. 66% of the patients were at term and 53.7% had early-onset sepsis. 74.6% of the cases were cesarean section and 59.5% were above 2500 grams. Coagulase-negative staphylococci (CNS) were the most common organisms grown in early and late-onset sepsis. 73.9% CNS, 9% Gram-negative enteric and nonfermentary bacilli, 2.9% Gram-positive bacilli and 0.1% fungi were grown. 40% of S.aureus were methicillin resistant. The most antimicrobial-resistant Gram-negative agent was Klebsiella spp. Klebsiella spp. isolates were resistant to amikacin 9%, ampicillin 100%, cefepime 72.7%, ceftazidime 81.8%, gentamicin 81.8%, meropenem 9.1%. Extended spectrum beta lactamase was positive in 90.9%. Acinetobacter spp. isolates were resistant to amikacin 42.8%, ampicillin 42.8%, gentamicin 42.8%, meropenem 42.8%. Conclusion: Microorganism species and antibiotic susceptibilities in intensive care units vary over time and between clinics. Broad-spectrum antimicrobials started early with suspicion of sepsis without culture confirmation can be replaced with agentspecific narrow-spectrum antimicrobials when growth is detected in culture,monotherapy can be switched or treatment can be terminated early. This may contribute to the prevention of resistance development. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BLOOD
*BACTEREMIA
*KLEBSIELLA
*CELL culture
*NEONATAL intensive care
*ACINETOBACTER infections
*CHILDREN'S hospitals
*NEONATAL intensive care units
*RETROSPECTIVE studies
*ACQUISITION of data
*DRUG resistance
*SEPSIS
*STAPHYLOCOCCAL diseases
*DISEASE susceptibility
*MEDICAL records
*DESCRIPTIVE statistics
*BETA lactamases
*DRUG resistance in microorganisms
*GRAM-negative bacterial diseases
*ANTIBIOTICS
Subjects
Details
- Language :
- Turkish
- ISSN :
- 13049054
- Volume :
- 21
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Journal of Current Pediatrics / Guncel Pediatri
- Publication Type :
- Academic Journal
- Accession number :
- 171834385
- Full Text :
- https://doi.org/10.4274/jcp.2023.01069