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Discovery selective acetylcholinesterase inhibitors to control Tetranychus urticae (Acari: Tetranychidae).
- Source :
-
Journal of Insect Science . Jul2023, Vol. 23 Issue 4, p1-8. 8p. - Publication Year :
- 2023
-
Abstract
- The two-spotted spider mite, Tetranychus urticae Koch, has a broad host plant range and presents an extreme capacity for developing pesticide resistance, becoming a major economic pest in agriculture. Anticholinesterase insecticides still account for a big part of global insecticide sales. However, there is a growing concern about the serious resistance problems of anticholinesterase insecticides and their nontarget toxicity. In this study, structure-based virtual screening was performed to discover selective AChE inhibitors from the ChemBridge database, and 39 potential species-specific AChE inhibitor were obtained targeting T. urticae AChE, but not human AChE. Among them, compound No. 8 inhibited AChE from T. urticae , but not from human, and had an inhibitory activity comparable to that of eserine. Compound No. 8 had dose-dependent toxicity to T. urticae in glass slide-dipping assay and had significant mite control effects in a pot experiment, but required a high concentration to achieve similar control effects to spirodiclofen. The toxicity evaluation suggested that compound No. 8 had no acute toxicity on pollinator honey bees and natural predator N. californicus and did not affect strawberry growth in our assay. Compound No. 8 is a potential lead compound for developing novel acaricides with reduced nontarget toxicity. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15362442
- Volume :
- 23
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Journal of Insect Science
- Publication Type :
- Academic Journal
- Accession number :
- 171832896
- Full Text :
- https://doi.org/10.1093/jisesa/iead073