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Influence of Season on Efficacy and Tolerability of Tazarotene 0.045% Lotion for the Treatment of Acne.
- Source :
-
Journal of Clinical & Aesthetic Dermatology . Sep2023, Vol. 16 Issue 9, p42-45. 4p. - Publication Year :
- 2023
-
Abstract
- OBJECTIVE: The condition of the skin can vary due to weather fluctuations. Therefore, this post-hoc analysis evaluated efficacy and safety of tazarotene 0.045% lotion in warmer versus colder months. METHODS: In two Phase III, double-blind, 12-week studies, participants aged nine years or older with moderate-to- severe acne were randomized 1:1 to once-daily tazarotene or vehicle lotion. The pooled population (N=1,614) was stratified by randomization date (warmer=May to September; colder=October to April). Evaluations included inflammatory/noninflammatory lesion counts, treatment success, adverse events, and safety/tolerability. RESULTS: Tazarotene 0.045% lotion was similarly efficacious over colder and warmer months. Compared with vehicle, tazarotene demonstrated significantly greater least-squares mean absolute reductions from baseline to Week 12 in inflammatory (colder/warmer tazarotene vs. vehicle: -16.6/-15.8 vs. -13.2/-12.9) and noninflammatory lesions (-23.2/-22.6 vs. -17.5/-15.1); treatment success rates were also significantly higher (30.1/30.8% vs. 18.2/17.6%) (P<0.001, all). No strong seasonal trends in safety were observed, though tazarotene led to slightly more discontinuations (3.4% vs. 1.9%) and related adverse events (12.0% vs. 10.3%) in colder versus warmer months. Transient increases in scaling, erythema, and itching at Weeks 2 to 8 of tazarotene treatment were slightly higher in colder versus warmer months but returned to baseline/improved by Week 12. LIMITATIONS: Geographical variation across study sites can lead to varying temperatures and humidity within the same months. CONCLUSION: Tazarotene 0.045% lotion was efficacious and well tolerated for acne treatment, regardless of season. Year-round tolerability of tazarotene 0.045% lotion may be due to its lower tazarotene concentration and polymeric emulsion technology, which simultaneously delivers moisturizers/humectants/emollients to skin. [ABSTRACT FROM AUTHOR]
- Subjects :
- *OINTMENTS
*ACNE
*SEASONS
*DRYING agents
*HUMIDITY
*ITCHING
Subjects
Details
- Language :
- English
- ISSN :
- 19412789
- Volume :
- 16
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Journal of Clinical & Aesthetic Dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 171795651