慢性肾脏病腹膜透析患者尿白蛋白水平与冠状动脉钙化的相关性.

Aim To investigate the correlation between urinary albumin (UAlb) level and coronary artery calcification (CAC) in patients with chronic kidney disease (CKD) undergoing peritoneal dialysis (PD). Methods 186 CKD patients hospitalized in Xianyang Central Hospital for PD treatment from February 2020 to June 2022 were selected as research objects and included in the training set; according to Rumberger CAC grading method, they were divided into noncalcification group (0 ~ 10 points, 80 cases) and calcification group (>10 points, 106 cases); according to the same criteria, 62 CKD patients hospitalized in Xianyang Central Hospital for PD treatment from July 2022 to November 2022 were included in the validation set. The clinical data of the two groups were compared and analyzed. The threshold effect of UAlb was determined by curve fitting and threshold effect analysis. Multivariate Logistic regression was used to analyze the risk factors affecting the occurrence of CAC, and an nomogram prediction model was constructed and evaluated. Results When UAlb>30 mg / L, the risk of CAC increased with the increase of its level. Age>50 years old, dialysis time>20 months, diabetes, neutrophil-to-lymphocyte ratio (NLR)≥3. 5, phosphorus≥1. 8 mmol / L, and UAlb>30 mg / L were independent risk factors for CAC (P<0. 05). The evaluation results showed that the discrimination, accuracy and effectiveness of the nomograph prediction model were high. Conclusions When UAlb>30 mg / L, the risk of CAC increases with its level. Age>50 years old, dialysis time>20 months, diabetes, NLR≥3. 5, phosphorus≥1. 8 mmol / L, UAlb>30 mg / L are all independent risk factors for CAC. [ABSTRACT FROM AUTHOR]