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Prospective network analysis of proinflammatory proteins, lipid markers, and depression components in midlife community women.
- Source :
-
Psychological Medicine . Aug2023, Vol. 53 Issue 11, p5267-5278. 12p. - Publication Year :
- 2023
-
Abstract
- Background: Vulnerability theories propose that suboptimal levels of lipid markers and proinflammatory proteins predict future heightened depression. Scar models posit the reverse association. However, most studies that tested relationships between non-specific immune/endocrine markers and depression did not separate temporal inferences between people and within-person and how different immunometabolism markers related to unique depression symptoms. We thus used cross-lagged prospective network analyses (CLPN) to investigate this topic. Methods: Community midlife women (n = 2224) completed the Center for Epidemiologic Studies-Depression scale and provided biomarker samples across five time-points spanning 9 years. CLPN identified significant relations (edges) among components (nodes) of depression (depressed mood, somatic symptoms, interpersonal issues), lipid markers [insulin, fasting glucose, triglycerides, low-density lipoprotein-cholesterol (LDL), high-density lipoprotein-cholesterol (HDL)], and proinflammatory proteins [C-reactive protein (CRP), fibrinogen], within and across time-points. All models adjusted for age, estradiol, follicle-stimulating hormone, and menopausal status. Results: In within-person temporal networks, higher CRP and HDL predicted all three depression components (d = 0.131–2.112). Increased LDL preceded higher depressed mood and interpersonal issues (v. somatic symptoms) (d = 0.251–0.327). Elevated triglycerides predicted more somatic symptoms (v. depressed mood and interpersonal problems) (d = 0.131). More interpersonal problems forecasted elevated fibrinogen and LDL levels (d = 0.129–0.331), and stronger somatic symptoms preceded higher fibrinogen levels (d = 0.188). Conclusions: Results supported both vulnerability and scar models. Long-term dysregulated immunometabolism systems, social disengagement, and related patterns are possible mechanistic accounts. Cognitive-behavioral therapies that optimize nutrition and physical activity may effectively target depression. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PROTEINS
*BIOMARKERS
*TRIGLYCERIDES
*C-reactive protein
*INFLAMMATION
*LDL cholesterol
*PSYCHOLOGICAL tests
*PHYSICAL activity
*MENTAL depression
*CENTER for Epidemiologic Studies Depression Scale
*AFFECTIVE disorders
*FIBRINOGEN
*HIGH density lipoproteins
*LIPIDS
*WOMEN'S health
*COGNITIVE therapy
*MIDDLE age
Subjects
Details
- Language :
- English
- ISSN :
- 00332917
- Volume :
- 53
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Psychological Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 171577645
- Full Text :
- https://doi.org/10.1017/S003329172200232X