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3-Halopyrazolo[1,5-a]pyrimidines as promising precursors of novel C-nucleosides.
- Source :
-
Russian Chemical Bulletin . Aug2023, Vol. 72 Issue 8, p1821-1836. 16p. - Publication Year :
- 2023
-
Abstract
- Various approaches to the synthesis of 3-halopyrazolo[1,5-a]pyrimidines were studied. It is shown that the most effective strategy consists in the construction of the azoloazine core followed by halogenation with N-iodo- or N-bromosuccinimide. A series of 3-halopyrazolo[1,5-a]pyrimidines, which are bioisosteric analogs of natural purine nucleic bases and the drug Triazavirin®, were synthesized using this strategy. The obtained compounds are interesting as precursors of novel C-nucleosides, which can be synthesized by C-C-coupling with (pseudo)ribosides containing a keto group. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HALOGENATION
*NUCLEOSIDE derivatives
*PYRIMIDINES
*REMDESIVIR
Subjects
Details
- Language :
- English
- ISSN :
- 10665285
- Volume :
- 72
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Russian Chemical Bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 171386958
- Full Text :
- https://doi.org/10.1007/s11172-023-3965-0