Preventive interventions for individuals at risk of developing bipolar disorder: A systematic review and meta-analysis.

This systematic review and meta-analysis aimed to explore whether early interventions can reduce affective symptoms and have long-term benefits among individuals at risk of bipolar disorder (BD). The PubMed, Embase, and Web of Science databases were searched. The primary outcome was continuous symptom scores before and after treatment. Random effects meta-analyses were conducted for each outcome arm studied and pooled mean difference estimates were calculated. The search identified 10 controlled studies involving 425 participants and 6 single-arm studies involving 90 participants. For controlled trials, meta-analysis showed that the interventions led to greater reduction in clinical global score than placebo (standardized mean differences (SMD) = −0.96, 95 % CI:-1.32, −0.60), and supported a long-term longitudinal effect for pharmacotherapy (SMD = −0.42, 95 % CI: −0.79, −0.05). For single-arm trials, both pharmacotherapy and psychotherapy showed efficacy for depressive symptoms, while pharmacotherapy only showed efficacy for hypomania symptoms (effect size (ES) = −9.16, 95 % CI:-11.29, −7.04). Discontinuation of pharmacotherapy due to adverse effects did not show a difference. The primary limitations are the small number of RCTs and the influence of medication dosage. Based on the limited available data, early interventions show efficacy for individuals at risk of BD. Psychological therapy might be more beneficial for depressive symptoms and have long-term benefits for hypomania. Pharmacotherapy may be appropriate in situations of severe hypomanic symptoms and the poor functioning. Large, well-designed, double-blind -controlled trials are needed to make solid conclusions about the efficacy of early interventions. • This meta-analysis has demonstrated that early interventions show efficacy for individuals at high risk of BD. • The psychological interventions might be suitable for depressive symptoms and have long-term benefits for mania symptoms. • The pharmacotherapy may be appropriate in situations of severe hypomanic symptoms and the poor functioning. [ABSTRACT FROM AUTHOR]