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Use of Interferon-Gamma Release Assays in Children <2 Years Old.
- Source :
-
Journal of the Pediatric Infectious Diseases Society . Aug2023, Vol. 12 Issue 8, p481-485. 5p. - Publication Year :
- 2023
-
Abstract
- While interferon-gamma release assays (IGRAs) are widely used for detecting tuberculosis (TB) infection, tuberculin skin tests (TSTs) remain preferred for children under the age of 2 years. The preference for TST stems from concern over IGRA sensitivity in young children. However, TSTs are susceptible to false-positive results following Bacille Calmette-Guérin (BCG) vaccination, which is common in infancy, and exposure to nontuberculous mycobacteria. We reviewed available data for IGRA performance in children under age 2 years. Across four cohorts of high-risk children under age 2 (mostly case contacts or those born in tuberculosis endemic regions), 0 of 575 untreated children with negative IGRA test results progressed to tuberculosis disease—including 0 of 70 who were TST positive but IGRA negative. While neither TSTs nor IGRAs are perfectly sensitive for the diagnosis of tuberculosis infection, IGRAs are an acceptable alternative to TST in children <2 years of age. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20487193
- Volume :
- 12
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Journal of the Pediatric Infectious Diseases Society
- Publication Type :
- Academic Journal
- Accession number :
- 171352514
- Full Text :
- https://doi.org/10.1093/jpids/piad053