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The effect of vitamin D on neurocognitive functions in older vitamin D deficient adults: a pilot longitudinal interventional study.
- Source :
-
Psychogeriatrics . Sep2023, Vol. 23 Issue 5, p781-788. 8p. 1 Chart. - Publication Year :
- 2023
-
Abstract
- Background: The relationship between vitamin D and cognitive status remains controversial. We aimed to evaluate the effect of vitamin D replacement on cognitive functions in healthy and cognitively intact vitamin D deficient older females. Methods: This study was designed as a prospective interventional study. A total of 30 female adults aged ≥60 with a serum 25 (OH) vitamin D level of <10 ng/ml were included. Participants were administered 50 000 IU vitamin D3 weekly for 8 weeks followed by a maintenance therapy of 1000 U/day. Detailed neuropsychological assessment was performed prior to vitamin D replacement and repeated at 6 months by the same psychologist. Results: Mean age was 63 ± 6.7 years and baseline vitamin D level was 7.8 ± 2.0 (range: 3.5–10.3) ng/ml. At 6 months, vitamin D level was 32.5 ± 3.4 (32.2–55) ng/ml. The Judgement of Line Orientation Test (P = 0.04), inaccurate word memorizing of the Verbal Memory Processes Test (P = 0.02), perseveration scores of the Verbal Memory Processes Test (P = 0.005), topographical accuracy of the Warrington Recognition Memory Test (P = 0.002), and the spontaneous self‐correction of an error in the Boston Naming Test (P = 0.003) scores increased significantly, while the delayed recall score in the Verbal Memory Processes Test (P = 0.03), incorrect naming of words in the Boston Naming Test (P = 0.04), interference time of the Stroop Test (P = 0.05), and spontaneous corrections of the Stroop Test (P = 0.02) scores decreased significantly from baseline. Conclusion: Vitamin D replacement has a positive effect on cognitive domains related to visuospatial, executive, and memory processing functions. [ABSTRACT FROM AUTHOR]
- Subjects :
- *EXECUTIVE function
*DRUG efficacy
*PILOT projects
*STATISTICS
*ACADEMIC medical centers
*HIGH performance liquid chromatography
*CHOLECALCIFEROL
*DIETARY supplements
*RANDOMIZED controlled trials
*VITAMIN D
*NEUROPSYCHOLOGICAL tests
*DESCRIPTIVE statistics
*VITAMIN D deficiency
*STATISTICAL sampling
*DATA analysis
*DATA analysis software
*LONGITUDINAL method
*OLD age
Subjects
Details
- Language :
- English
- ISSN :
- 13463500
- Volume :
- 23
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Psychogeriatrics
- Publication Type :
- Academic Journal
- Accession number :
- 171350484
- Full Text :
- https://doi.org/10.1111/psyg.12997