Back to Search
Start Over
Study on Optimal Extraction and Hypoglycemic Effect of Quercetin.
- Source :
-
Evidence-based Complementary & Alternative Medicine (eCAM) . 8/29/2023, p1-9. 9p. 3 Charts, 3 Graphs. - Publication Year :
- 2023
-
Abstract
- Quercetin was extracted from Portulaca oleracea L. through biphasic acid hydrolysis to investigate its potential as a suppressor of dipeptidyl peptidase IV (DPP-IV) and its hypoglycemic effect in type 2 diabetic mice. The extraction procedure was optimized utilizing the response surface method (RSM) in a single-factor experimental setting. An extraction efficiency of 0.675% was achieved using the following optimized parameters: 0.064 mol/L vitriol, 1 : 109.155 solid-liquid ratio, and 21.408 min ultrasonication. Overall, findings indicate the effectiveness of quercetin extraction. A mouse model for type 2 diabetes was established to receive oral treatment with various quercetin concentrations for 8 weeks. Fasting blood glucose (FBG) and the DPP-IV activity in the serum were significantly reduced. The weight and insulin levels of the mice in the quercetin group were raised compared to those in the model group (P < 0.01). Quercetin dose-dependently inhibited postprandial blood glucose excursions, as demonstrated by the oral glucose tolerance test. These results confirmed that quercetin has hypoglycemic effects and considerably improves insulin sensitivity via DPP-IV targeting. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BLOOD sugar analysis
*PHYSICAL & theoretical chemistry
*HIGH performance liquid chromatography
*ANIMAL experimentation
*HYPOGLYCEMIC agents
*PROTEOLYTIC enzymes
*TYPE 2 diabetes
*QUERCETIN
*COMPARATIVE studies
*INSULIN sensitivity
*RESEARCH funding
*DESCRIPTIVE statistics
*PLANT extracts
*GLUCOSE tolerance tests
*MICE
*ULTRASONICS
Subjects
Details
- Language :
- English
- ISSN :
- 1741427X
- Database :
- Academic Search Index
- Journal :
- Evidence-based Complementary & Alternative Medicine (eCAM)
- Publication Type :
- Academic Journal
- Accession number :
- 171326982
- Full Text :
- https://doi.org/10.1155/2023/8886503