Electrochemical Decarboxylative Minisci-Type Acylation of Quinoxalines under Catalyst- and External-Oxidant-Free Conditions.

In these transformations, the stable and easily available -keto acids were employed as the acyl radical precursors, while iodide and nickel catalysis facilitate the acyl radical generation. Mechanistically, the Minisci-type acylation includes three key processes: acyl radical generation, radical addition of acyl radicals to N-heterocycles, and formal hydrogen atom loss. Keywords: electrosynthesis; Minisci reaction; acyl radical; -keto acids; anodic oxidation EN electrosynthesis Minisci reaction acyl radical -keto acids anodic oxidation 3026 3032 7 08/31/23 20230915 NES 230915 Graph The Minisci-type reaction constitutes a robust tactic to construct functionalized N-heterocycles via radical pathways in a single step. Electrosynthesis, Minisci reaction, -keto acids, acyl radical, anodic oxidation. [Extracted from the article]