Is Apaf-1 expression frequently abrogated in melanoma?

Presents a letter to the editor "Cell Death and Differentiation" journal concerning a study which indicated that the absence of caspase-9 coactivator Apaf-1 or the associated caspase-9 did not affect either apoptosis or drug sensitivity in a lymphoid tumor model or in primary lymphocytes, raising doubts that Apaf-1 is crucial to apoptosis.