血清乳酸脱氢酶评估颅脑手术患者重症肺炎的临床价值.

Objective: To analyze the value of serum lactate dehydrogenase in evaluating severe pneumonia in patients undergoing craniocerebral surgery. Methods: 268 patients undergoing selective craniocerebral surgery in our hospital from July 2020 to June 2022 were selected. They were divided into non infection group (n=185) and pneumonia group (n=83) according to whether they were complicated with postoperative pneumonia. The pneumonia group was divided into severe pneumonia 31 cases and common pneumonia 52 cases according to the severity of pneumonia. Serum PCT and CRP levels were measured by ELISA; The serum LDH level was detected by enzyme colorimetry, and the correlation between the serum LDH, PCT, CRP levels and the severity of the disease in patients with pneumonia was analyzed by Pearson correlation test. ROC curve was used to analyze the clinical diagnostic value of serum LDH, PCT, CRP levels in patients with severe pneumonia after craniocerebral surgery, and the prognostic value of serum LDH, PCT, CRP levels in patients with severe pneumonia after craniocerebral surgery. Results: The levels of serum LDH, PCT and CRP in patients with common pneumonia were significantly higher than those in the uninfected group on the 1st, 3rd and 7th day after operation (P<0.05); Compared with the common pneumonia group, the serum LDH, PCT and CRP levels in the severe pneumonia group were significantly higher (P<0.05). Pearson correlation test showed that serum LDH, PCT, CRP levels were positively correlated with PSI scores in patients with craniocerebral surgery complicated with pneumonia (P<0.05). The ROC curve was established based on the serum LDH, PCT and CRP levels on the first day after operation. The results showed that the areas under the curve of serum LDH, PCT and CRP were 0.840, 0.825 and 0.746 respectively. The ROC curve was established based on the serum LDH, PCT and CRP levels 7 days after operation. The results showed that the areas under the curve of serum LDH, PCT and CRP were 0.819, 0.725 and 0.684 respectively. Conclusion: LDH is highly expressed in patients with craniocerebral operation complicated with pneumonia, which is positively related to the severity of pneumonia. LDH has good value in distinguishing non severe pneumonia patients from severe pneumonia patients and predicting the 28 day mortality of severe pneumonia patients. [ABSTRACT FROM AUTHOR]