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Occurrence, placental transfer, and health risks of emerging endocrine-disrupting chemicals in pregnant women.

Authors :
Li, Aijing
Zhuang, Taifeng
Song, Maoyong
Cao, Huiming
Gao, Yue
Zheng, Shufa
Liang, Yong
Jiang, Guibin
Source :
Journal of Hazardous Materials. Oct2023, Vol. 459, pN.PAG-N.PAG. 1p.
Publication Year :
2023

Abstract

Previous studies demonstrated that many environmental chemicals can cross the human placental barrier. However, the risk regarding gestational exposure of emerging endocrine-disrupting chemicals (EDCs) is unclear. In this study, the occurrence of 24 EDCs, such as bisphenol A analogs, parabens, triclocarban, and triclosan, was investigated in serum and urine samples from Chinese pregnant women. Some metabolites were determined in matched serum–urine pairs (n = 75) to perform a comprehensive assessment of exposure. The placental transfer efficiency (PTE) of the detected chemicals was determined in matched maternal–cord serum pairs (n = 110). The mean PTEs of the chemicals showed a large variation from 43.1% to 171.0%. The potential effects of physicochemical properties, molecular structures, and biological factors on PTE were investigated using multiple linear regression models and molecular docking. We found that the PTE of methyl paraben, ethyl paraben, and propyl paraben was associated with their increasing alkyl chain lengths. Furthermore, a comprehensive exposure assessment of EDCs showed that 62.7% of pregnant women had a health index > 1, which indicted potential health risks during pregnancy. However, toxicity and the underlying mechanisms of these EDCs remain to be further studied. [Display omitted] • Twenty-four endocrine-disrupting chemicals (EDCs) were detected in pregnant women. • The placental transfer efficiency (PTE) of EDCs was measured. • The effects of physicochemical and biological factors on PTEs were investigated. • Potential health risks of target EDCs to pregnant women were proposed. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
03043894
Volume :
459
Database :
Academic Search Index
Journal :
Journal of Hazardous Materials
Publication Type :
Academic Journal
Accession number :
170720808
Full Text :
https://doi.org/10.1016/j.jhazmat.2023.132157