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Nickel-Catalyzed Asymmetric Arylation of H-Phosphinates.
- Source :
-
Synlett . Sep2023, Vol. 34 Issue 15, p1819-1823. 5p. - Publication Year :
- 2023
-
Abstract
- Keywords: phosphinates; P-stereogenic centers; nickel catalysis; cross-coupling; asymmetric catalysis EN phosphinates P-stereogenic centers nickel catalysis cross-coupling asymmetric catalysis 1819 1823 5 08/29/23 20230915 NES 230915 Graph P-Stereogenic organic phosphorus compounds, especially chiral phosphinic acid derivatives, are useful in medicinal chemistry, pesticide chemistry, organic materials science, and biochemistry. Moreover, when we employed aryl iodides with a free amino ( B 26 b ) or hydroxy group ( B 27 b ) at the I para i -position of the aryl ring, P-chiral phosphinates were obtained in moderate yields (71 and 68%) and high ee values (88 and 81% ee). [41] However, we found aryl iodides with different electronic properties all gave the corresponding P-chiral phosphinates with moderate to high ee values (62-82% ee); in other words, the enantioselectivity was only slightly affected by the electronic properties of the aryl iodides. During the preparation of our manuscript, Duan and our group separately reported Ni(0)-catalyzed intermolecular reactions of nonactivated aryl halides [39] and Ni(II)-catalyzed intermolecular reactions of heterocyclic halides, [40] respectively. [Extracted from the article]
Details
- Language :
- English
- ISSN :
- 09365214
- Volume :
- 34
- Issue :
- 15
- Database :
- Academic Search Index
- Journal :
- Synlett
- Publication Type :
- Academic Journal
- Accession number :
- 170719231
- Full Text :
- https://doi.org/10.1055/s-0042-1751456