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Trans-ε-viniferin as an inhibitor of TMEM16A preventing intestinal smooth muscle contraction.
- Source :
-
Journal of Asian Natural Products Research . Sep2023, Vol. 25 Issue 9, p867-879. 13p. - Publication Year :
- 2023
-
Abstract
- TMEM16A regulator is an important tool to study the physiological functions and pathogenesis related to TMEM16A. In the present study, trans-ε-viniferin (TV) was identified as a TMEM16A inhibitor with inhibitory activity against TMEM16A mediated Cl− currents, which was reversible, without affecting intracytoplasmic Ca2+ concentration and TMEM16A protein expression. TV inhibited intestinal peristalsis and prolonged gastrointestinal transport time. TV could inhibit autonomic and Eact-stimulated intestinal contractility, and was equally effective in ACh- and HA-induced high contractile states. The results indicate that TV significantly inhibits the intestinal smooth muscle contraction, which may be applied in the treatment of TMEM16A-related intestinal dynamic abnormalities. [ABSTRACT FROM AUTHOR]
- Subjects :
- *GASTROINTESTINAL motility
*SMOOTH muscle
*MUSCLE contraction
*CELL culture
*ANIMAL experimentation
*WESTERN immunoblotting
*ONE-way analysis of variance
*FLUORESCENCE spectroscopy
*RESVERATROL
*T-test (Statistics)
*MEMBRANE transport proteins
*DESCRIPTIVE statistics
*RESEARCH funding
*MOLECULAR structure
*DATA analysis software
*INTESTINES
*MICE
Subjects
Details
- Language :
- English
- ISSN :
- 10286020
- Volume :
- 25
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Journal of Asian Natural Products Research
- Publication Type :
- Academic Journal
- Accession number :
- 170718687
- Full Text :
- https://doi.org/10.1080/10286020.2023.2165067