Electrochemical Behavior of Epinephrine at a Penicillamine Self-Assembled Gold Electrode, and its Analytical Application.

The fabrication and electrochemical characteristics of a penicillamine (PCA) self-assembled monolayer modified gold electrode were investigated. The self-assembled electrode shows obvious electrocatalytic activity for the oxidation of epinephrine (EP). In phosphate buffer (pH 7.73), a sensitive oxidation peak was observed at 0.190?V with the PCA modified Au electrode. The peak current is proportional to the concentration of EP in the range of 2.0?×?10-5?~6.0?×?10-4?mol?L-1 and 5.0?×?10-6?~ 2.0?×?10-4?mol?L-1 for cyclic voltammetry (CV) and differential pulse voltammetry (DPV) with the detection limits of 1.8?×?10-7 and 1.3?×?10-7?mol?L-1, respectively. The possible reaction mechanism is also discussed. The PCA self-assembled monolayer modified gold electrode is highly stable and can be applied to the determination of EP in practical injection samples. Application is simple, rapid and produces accurate results. [ABSTRACT FROM AUTHOR]