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Cognitive Behavioral Therapy Guided Self-Help and Orlistat for the Treatment of Binge Eating Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial
- Source :
-
Biological Psychiatry . May2005, Vol. 57 Issue 10, p1193-1201. 9p. - Publication Year :
- 2005
-
Abstract
- Background: Cognitive behavioral therapy (CBT) has efficacy for binge eating disorder (BED) but not obesity. No controlled studies have tested whether adding obesity medication to CBT facilitates weight loss. We performed a randomized, placebo-controlled study of orlistat administered with guided self-help CBT (CBTgsh). Methods: Fifty obese BED patients were randomly assigned to 12-week treatments of either orlistat plus CBTgsh (120 mg three times a day [t.i.d.]) or placebo plus CBTgsh and were followed in double-blind fashion for 3 months after treatment. Results: Seventy-eight percent of patients completed treatments without differential dropout between orlistat+CBTgsh and placebo+CBTgsh. Intent-to-treat remission rates (zero binges for past 28 days on Eating Disorder Examination Interview) were significantly higher for orlistat+CBTgsh than placebo+CBTgsh (64% versus 36%) at posttreatment but not at 3-month follow-up (52% in both). Intent-to-treat rates for achieving 5% weight loss were significantly higher for orlistat+CBTgsh than placebo+CBTgsh at posttreatment (36% versus 8%) and 3-month follow-up (32% versus 8%). Significant and comparable improvements in eating disorder psychopathology and psychological distress occurred in both treatments. Conclusions: The addition of orlistat to CBTgsh was associated with greater weight loss than the addition of placebo to CBTgsh. Clinical improvements were generally maintained at 3-month follow-up after treatment discontinuation. [Copyright &y& Elsevier]
- Subjects :
- *ORLISTAT
*LIPASE inhibitors
*ANTIOBESITY agents
*BEHAVIOR therapy
*BULIMIA
*OBESITY
Subjects
Details
- Language :
- English
- ISSN :
- 00063223
- Volume :
- 57
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Biological Psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 17054441
- Full Text :
- https://doi.org/10.1016/j.biopsych.2005.03.001