莲生物碱生物合成途径及相关基因研究进展.

Many parts of lotus（Nelumbo nucifera Gaertn.）can be used as medicine, among which benzyl isoquinoline alkaloids are the main active components in lotus leaf and lotus plumule. The study found that lotus leaf contains nuciferine, roemerine and other aporphine alkaloids, with good lipid-lowering weight-reducing effect. Lotus plumule mainly contains bisbenzylisoquinoline alkaloids such as neferine and liensinine, which can resist arrhythmia. In recent years, the significant pharmacological activity of lotus alkaloids and the phenomenon of ‘homologous and different effects’between lotus leaf and lotus plumule have inspired more and more researchers to study the biosynthetic pathways and key enzymes of lotus alkaloids. Therefore, this paper reviews the research progress of alkaloid composition types, alkaloid synthesis pathways and key enzyme genes of lotus leaves and lotus plumule, aiming to provide reference for analyzing the alkaloid synthesis pathways of lotus and the molecular mechanisms of pharmacodynamic differentiation of lotus leaves and lotus plumule. [ABSTRACT FROM AUTHOR]