Comparison Of Ropivacaine Hydrochloride With Two Doses Of Clonidine Hydrochloride Under Spinal Anaesthesia In Anorectal Surgeries.

Background: Addition of clonidine to ropivacaine intrathecally has been found to improve quality and duration of sensory and motor blockade alongwith improvement in postoperative analgesia. In our study we compared ropivacaine alone and in combination with different doses of clonidine. Material and Methods: The randomised doubleblind study was conducted on 90 patients aged 20- 65years withASA grade I-III posted for elective anorectal surgeries of duration less than 90 minutes under spinal anaesthesia.Patients were randomly divided into three groupsof 30 each. Group I received (18.75 mg)plain ropivacaine. Group II received 18.75 mg ropivacaine and 50 µg clonidine and Group III received 18.75 mg ropivacaine and 75 µg clonidine. Onset and duration of sensory and motor blockade, haemodynamic changes, postoperative analgesia, sedation score and side effects were compared between the groups. Results: The time of request of first analgesia was longest in group III( 611.33 minutes) which was significantly greater than group II (426.96 minutes) and group I (220 minutes).The difference in the sedation score between group I and group II was statistically non-significant and difference between group I and III and group II and III was highly significant. There was no incidence of delayed micturition in group I, 4(13,33%) in group II and 6(20%) in group III ConclusionAddition of both 50 and 75µg of clonidine to ropivacine significantly prolonged duration of analgesia with lesser number of rescue analgesia and reduced VAS score but there were more incidence of sedation, hypotension and delayed micturition with 75 µg of clonidine. [ABSTRACT FROM AUTHOR]