VITAMIN D3 AND THE RISK OF DIABETIC NEPHROPATHY: A CROSS-SECTIONAL STUDY.

Background and objectives: Vitamin D has a significant impact on glucose metabolism. Increased insulin exocytosis, direct activation of insulin receptors, and increased glucose absorption by peripheral tissues all contribute to decreased insulin resistance. The study's goal is to look at vitamin D levels in people with type 2 diabetes and how they relate to diabetic nephropathy. Material and Method: This study lasted, from March, 2022 to February, 2023, at Department of General Medicine, Katuri Medical College and Hospital, Guntur, Andhra Pradesh, India. The connection between circulating vitamin D levels and the presence of diabetic nephropathy in type 2 diabetes mellitus outpatients and inpatients of medical wards was investigated in this cross-sectional investigation. Result: Our study included 200 patients, 100 of whom were female and 100 of whom were male. When comparing genders, there is a statistically significant increase in female patients with Vitamin D. Here, 70 patients with vitamin D shortage were found to have diabetic nephropathy, which is statistically insignificant, and 30 patients with vitamin D sufficiency were found to have diabetic nephropathy, which is statistically negligible. Conclusion: Vitamin D has been found to have both direct and indirect action via vitamin D receptor activation, as well as effects on various pathogenesis and type 2 diabetes, including pancreatic beta cell dysfunction, insulin action impairment, and systematic information. [ABSTRACT FROM AUTHOR]