STUDY OF SERUM FERRITIN AND GLYCOSYLATED HEMOGLOBIN LEVELS IN TYPE 2 DIABETES MELLITUS.

Introduction: Type 2 Diabetes Mellitus is one of the most common metabolic endocrine disorder characterised by hyperglycemia. It is caused by a complex interaction of genetics and environmental factors. In DM, lipid abnormalities, anaemia, alteration of liver and kidney functional indices have been implicated as major risk factors to the progression of Diabetic complications. Ferritin is an index of body iron stores & acts as an iron overload marker. The relationship between iron metabolism and type 2 DM is bidirectional. Iron is a potent pro-oxidant that increases cell oxidative stress causing decreased insulin internalization and actions resulting in hyperinsulinemia and insulin resistance. Serum Ferritin, an acute phase reactant is a marker of iron stores in the body. Increased serum ferritin, reflecting body iron overload, is often associated with measures of insulin resistance, such as elevated blood glucose and insulin levels. Aims and Objectives a) To measure the level of Serum Ferritin and glycosylated hemoglobin in patient with Type-2 Diabetes mellitus b) To measure the level of Serum Ferritin and glycosylated hemoglobin in controls. Materials and Methodology: This is a case control study.The study duration is 2 years. The study was carried out on 75 cases of clinically diagnosed type 2 diabetes mellitus in the age group 40-60 years, attending department of medicine, KIMS, Koppal. Seventy five age and sex matched healthy subjects were taken as controls. Ethical clearance was obtained from institutional ethical clearance committee.Venous sample was collected and serum biochemical parameters( FBS, PPBS, HbA1C, Ferritin) were measured. Statistical Test: Data is expressed in terms of mean ± SD. Chi- square test was applied to estimate the difference between the two groups of population. Unpaired ‘t’-test was used to study the changes in serum ferritin levels between the study groups. p value <0.05 was considered statistically significant. Results: The study showed statistically significant increase(p<0.05) in serum ferritin levels in cases compared to controls. Our study showed a positive correlation between ferritin and blood sugar levels. Conclusion: Type 2 Diabetes mellitus is associated with increased ferritin levels .Reliable and sensitive methods need to be developed to precisely measure catalytic iron that participates in oxidative injury. [ABSTRACT FROM AUTHOR]