Thyroid-stimulating hormone, Malonaldehyde and Protein Carbonyls in Hypothyroidism.

Background: Oxidative stress (SOX) has been frequently correlated with hypothyroidism. SOX are openly produced during the overproduction of TSH. Hence there may be higher lipoxidation and protein carbonylation. Although, the link between oxidation of lipid and protein has not been well illustrated in circumstances of elevated TSH levels. Material and Methods: Approximation of free T3 levels, free T4 levels, TSH levels, peroxidation of lipids like MDA levels, and carbonylation of proteins as PCO were projected in hypothyroidism. Around 175 patients in each diseased category, against 175 euthyroid controls were taken under study. The links between MDA, TSH, and PCO were also calculated. Results: Noteworthy rise in MDA and PCO levels in hypothyroidism reflected enlarged oxidative damage when compared with the euthyroid group (p<0.01). MDA and TSH levels had a significant relationship with PCO in both hypothyroid patients. Investigation of Pearson partial correlation exposed a mutual relationship of overloaded TSH levels and increased MDA levels in manipulating the increase of PCO in clinical and subclinical hypothyroidism. Conclusion: Parallel damage to MDA and PCO was seen due to enhanced oxidative stress in both hypothyroid patients leading to lipoxidation and protein carbonylation. Excess TSH and high MDA levels may be cumulatively caught up in the rise of protein carbonylation in hypothyroidism. [ABSTRACT FROM AUTHOR]