CARDIAC MARKERS IN ACUTE ORGANOPHOSPHOROUS POISONING.

Background: Organophosphorous (OP) compound poisoning is a common toxological emergency in agricultural country like India, as it is easily available. Cardiac Marker (CPKMB &Trop-I) level were frequently elevated in OPC poisoning and ECG changes were observed. Fatality is mostly due to cardiovascular and respiratory failure. Aim & Objective: To study clinical severity and it's correlation to myocardial injury in respect to Troponine-I, CPK-MB and ECG changes. Material and Methods: A prospective observational study conducted among 97 patients admitted in Medicine Department, VIMSAR, Burla with history of OPC poisoning during the period of Dec 2019 to Dec 2021 after approval from institutional Ethical Committee. Changes in ECG, Serum CPK-MB, Trop-I level were estimated by IFCC and ELISA method, respectively and observed at admission, after 3 days and at discharge. Results: Mostly Chlorpyriphos (23.7%) was consumed followed by Phorate (22.7%). The most common clinical symptoms was bradycardia (49.5%) followed by hypotension (26.8%), and tachycardia (21.6%). Acetylcholine esterase level decreased (<25000IU) in 75.3 % patients. ECG showed Sinus bradycardia (44.3%), followed by QT prolongation (33%). On day3, significantly elevated Trop-I (27.80 %) and CPK-MB(29.89%) were found. Conclusion: Majority of the patients were in the age group of 45-60 with males more than females. Occurrence of cardiotoxicity was related to the type of compounds ingested. Elevated CPK-MB and Trop-I indicates severity of OPC poisoning requiring longer ICU stay and also statistically significant to predict the prognosis of poisoning. [ABSTRACT FROM AUTHOR]