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Deuteration Degree‐Controllable Methylation via a Cascade Assembly Strategy using Methylamine‐Water as Methyl Source.
- Source :
-
Chemistry - A European Journal . 8/10/2023, Vol. 29 Issue 45, p1-7. 7p. - Publication Year :
- 2023
-
Abstract
- We present a novel and effective photocatalytic method for the methylation of β‐diketones with controllable degrees of deuterium incorporation via development of new methyl sources. By utilizing a methylamine‐water system as the methyl precursor and a cascade assembly strategy for deuteration degree control, we synthesized methylated compounds with varying degrees of deuterium incorporation, showcasing the versatility of this approach. We examined a range of β‐diketone substrates and synthesized key intermediates for drug and bioactive compounds with varying degrees of deuterium incorporation, ranging from 0 to 3. We also investigated and discussed the postulated reaction pathway. This work demonstrates the utility of readily available reagents, methylamines and water, as a new methyl source, and provides a simple and efficient strategy for the synthesis of degree‐controllable deuterium‐labelled compounds. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DEUTERATION
*METHYLATION
*DEUTERIUM
*DOSAGE forms of drugs
*BIOACTIVE compounds
Subjects
Details
- Language :
- English
- ISSN :
- 09476539
- Volume :
- 29
- Issue :
- 45
- Database :
- Academic Search Index
- Journal :
- Chemistry - A European Journal
- Publication Type :
- Academic Journal
- Accession number :
- 169875218
- Full Text :
- https://doi.org/10.1002/chem.202301458