A whole-genome reference panel of 14,393 individuals for East Asian populations accelerates discovery of rare functional variants.

The article informs A comprehensive whole-genome reference panel containing over 14,000 individuals from East Asian populations has been created, accelerating the identification of rare functional genetic variants. This reference panel greatly enhances imputation accuracy for rare and low-frequency variants within East Asian populations, leading to the discovery of previously unidentified associations and genes with significant effects on phenotypes.