Design, synthesis, characterization, docking studies of novel 4-phenyl acrylamide-1,3-thiazole derivatives as anti-inflammatory and anti-ulcer agents.

• Synthesis of thiazole appended phenyl acrylamide 1,3-thiazole derivatives (7a-j). • All the synthesized compounds were recognized by IR, NMR, and mass spectral data. • Evaluated the synthesized series for anti-inflamatory and anti-ulcer activity. • Synthesized compounds possess good anti-inflammatory and anti-ulcer activity which was evaluated in-vitro , and in-silico studies. • Compound (7e) with electron releasing methyl group has strongest contact with the active site of H +/ K + ATPase. A great extent of nitrogen containing heterocyclic moiety comprising sulfur atom is recognized as a valuable combination of therapeutics in medicinal chemistry. In particular, thiazoles analogs play a very significant pharmacological role in many potent biological activities, hence drugs like tiazofurin, abafungin, meloxicam, fanetinole, sulphathiazole and thiamine are well known in market. The incorporation of the thiaazole ring can offer enhanced physical-chemical properties to show a wide scope of targets and diverse biological applications. In this view, the title compounds 7(a-j) were synthesized in good yield. The purified compounds were explained by spectroscopic procedures (FT-IR, 1H NMR, 13CNMR, and LC-MS), and lastly, Among the series of (7a-j), compound (7e) showed maximum selectivity for COX-2 with an IC 50 of 8.68±0.31 μM, and the rest of the compounds lies at just below the (7e) which reveals that this compound is quite effective for COX-1 rather than COX-2. The activity found in compound (7e) is attributable to the presence of electron releasing methyl group that has the strongest contact with the active site of H +/ K + ATPase in this study. [ABSTRACT FROM AUTHOR]