Editorial on Special Issue "Lipid Nanosystems for Local Drug Delivery".

Among these, lipid-based nanosystems (e.g., liposomes, solid lipid nanoparticles, nanostructure lipid carriers, and nanoemulsions) possess enormous potential due to their ability to improve drug delivery, enhance therapeutic efficacy, and enable the targeted and controlled release of bioactive compounds. Therefore, lipid-based nanosystems have been demonstrated as one of the most effective strategies for improving skin permeability by fluidizing the lipid matrix of the stratum corneum without interfering with the skin barrier's functions. This Special Issue's review papers have addressed significant themes for researchers working in the following areas of interest: (i) the application of microfluid technology to prepare lipid-based nanosystems [[8]]; (ii) the application of lipid nanosystems intended for topical and transdermal drug delivery [[9]]; and (iii) the utilization of antibody-conjugated lipid nanosystems in anticancer drug delivery to achieve an active targeting strategy. [Extracted from the article]