A Neural Network for Predicting the Stability of DNA/DNA Duplexes.

Authors :: Liu, Xiaohong
Ma, Lixin
Cheng, Changmei
Wang, Yong
Miyajima, Hiromi
Zhao, Yufen
Source :: Nucleosides, Nucleotides & Nucleic Acids. Mar2005, Vol. 24 Issue 3, p199-209. 11p. 1 Diagram, 7 Charts, 2 Graphs.
Publication Year :: 2005
Abstract: A back-propagation neural network method has been developed to predict the stability of DNA/DNA duplexes. Calculated T m with the present parameters fits the experimental values within reasonable errors (AD = 1.86 K, SEP = 1.99151, R2 = 0.9894 for NN1; AD = 1.59667 K, SEP = 2.03824, R2 = 0.99371 for NN2), and it has the advantage that the determinations of thermodynamic parameters are not needed. [ABSTRACT FROM AUTHOR]