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Design, synthesis and biological evaluation of novel, simplified analogues of laulimalide: modification of the side chain
- Source :
-
Bioorganic & Medicinal Chemistry Letters . May2005, Vol. 15 Issue 9, p2243-2247. 5p. - Publication Year :
- 2005
-
Abstract
- Abstract: Novel, simplified analogues of the microtubule-stabilizing anticancer agent laulimalide, including the first derivatives with unnatural side chains, were designed by molecular modelling, synthesized by a late-stage diversification strategy, and evaluated in vitro for growth inhibition of human ovarian carcinoma cell lines (A2780, A2780/AD10). [Copyright &y& Elsevier]
- Subjects :
- *ANTINEOPLASTIC agents
*CELL culture
*CANCER
*CELL lines
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 15
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 16941137
- Full Text :
- https://doi.org/10.1016/j.bmcl.2005.03.018