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Inflammatory cytokines as potential biomarkers for early diagnosis of severe malaria in children in Ghana.

Authors :
Obeng-Aboagye, Elizabeth
Frimpong, Augustina
Amponsah, Jones Amo
Danso, Samuel E.
Owusu, Ewurama D. A.
Ofori, Michael Fokuo
Source :
Malaria Journal. 7/31/2023, Vol. 22 Issue 1, p1-8. 8p.
Publication Year :
2023

Abstract

Background: Severe malaria (SM) is a fatal multi-system disease which accounted for an estimated 619,000 deaths in 2021. Less than 30% of children presenting with SM are diagnosed and treated promptly, resulting in increased mortality and neurologic impairments in survivors. Studies have identified cytokine profiles that differentiate the various clinical manifestations of malaria (severe and uncomplicated). However, the diagnostic capability of these cytokines in differentiating between the disease states in terms of cut-off values has not yet been determined. Methods: The plasma levels of 22 pro-inflammatory cytokines (Eotaxin/CCL 11, interferon-gamma (IFN-γ), interleukin (IL)- 2, IL-6, IL-1β, IL-12p40/p70, IL-17A, RANTES, MCP-1, IL-15, IL-5, IL-1RA, IL-2R, IFN-α, IP-10, TNF, MIG, MIP-1α, MIP-1β, IL-7, IL-8 and Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF), and 3 anti-inflammatory cytokines-(IL-4, IL-13 and IL-10) in patients with SM, uncomplicated malaria (UM) and other febrile conditions, were measured and compared using the Human Cytokine Magnetic 25-Plex Panel. The receiver operating characteristic (ROC) curve analysis was used to determine the diagnostic value of these cytokines. Results: The level of the pro-inflammatory cytokine, IL-17A, was significantly higher in the SM group as compared to the UM group. Levels of the anti-inflammatory cytokines however did not differ significantly among the SM and UM groups. Only IL-1β and IL-17A showed good diagnostic potential after ROC curve analysis. Conclusion: The data show that levels of pro-inflammatory cytokines correlate with malaria disease severity. IL-1β and IL-17A showed good diagnostic potentials and can be considered for use in clinical practice to target treatment. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14752875
Volume :
22
Issue :
1
Database :
Academic Search Index
Journal :
Malaria Journal
Publication Type :
Academic Journal
Accession number :
169326344
Full Text :
https://doi.org/10.1186/s12936-023-04652-w