Back to Search Start Over

Cutaneous Malignant Melanoma Metastatic to the Larynx and Trachea: A Case Report and Review of the Literature.

Authors :
Ciolofan, Mircea Sorin
Mogoantă, Carmen Aurelia
Ioniță, Iulică
Mitroi, Mihaela Roxana
Mitroi, George F.
Anghelina, Florin
Vlăescu, Alexandru Nicolae
Căpitănescu, Alina Nicoleta
Vîlcea, Alina Maria
Mitroi, George G.
Ică, Oana Maria
Stoica, Loredana Elena
Source :
Life (2075-1729). Jul2023, Vol. 13 Issue 7, p1452. 12p.
Publication Year :
2023

Abstract

Malignant melanoma rarely develops in mucous membranes. Statistical data show that approximately 0.6–9.3% of patients with cutaneous malignant melanoma will develop metastases in the upper aerodigestive tract mucosa, and within these metastatic sites, the least common are the laryngeal and tracheobronchial ones. This exceedingly rare clinical entity has no clear treatment recommendations; radical surgery does not seem to benefit the patient in term of life expectancy. We present the case of a 56-year-old male patient diagnosed with laryngeal and tracheobronchial melanoma metastases. Prior to admission to our clinic the patient had a personal history of malignant melanoma of the nuchal region operated on 7 years ago, malignant melanoma of the gallbladder and metastatic left axillary polyadenopathy for which he underwent surgical treatment 3 months prior. Histopathological and immunohistochemical reports established the diagnosis of laryngeal metastasis of malignant melanoma. Genetic molecular analysis was positive for B-Raf (BRAF) gene and hence Vemurafenib was administered, with a favorable outcome at the one-year follow-up. Nevertheless, there are currently no clear universally accepted guidelines for the treatment of laryngeal melanoma, mainly due to the rarity of this clinical entity. We conducted a review of similar cases reported in the literature. Interestingly, reviewing the cases reported in the literature, it appears that laryngeal metastases of a primary cutaneous melanoma are more common in men, with an average time to metastasis of 4.3 years. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20751729
Volume :
13
Issue :
7
Database :
Academic Search Index
Journal :
Life (2075-1729)
Publication Type :
Academic Journal
Accession number :
169325661
Full Text :
https://doi.org/10.3390/life13071452