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Evolution of Cognitive Impairments in Treatment-Resistant Depression: Results from the Longitudinal French Centers of Expertise for Treatment-Resistant Depression (FACE-DR) Cohort.

Authors :
Vancappel, Alexis
Dansou, Yecodji
Godin, Ophelia
Haffen, Emmanuel
Yrondi, Antoine
Stephan, Florian
Richieri, Raphaelle Marie
Molière, Fanny
Holtzmann, Jérôme
Horn, Mathilde
Allauze, Etienne
Genty, Jean Baptiste
Bouvard, Alex
Dorey, Jean-Michel
Hennion, Vincent
Camus, Vincent
Fond, Guillaume
Peran, Barbara
Walter, Michel
Anguill, Loic
Source :
Brain Sciences (2076-3425). Jul2023, Vol. 13 Issue 7, p1120. 14p.
Publication Year :
2023

Abstract

Previous studies set out profound cognitive impairments in subjects with treatment-resistant depression (TRD). However, little is known about the course of such alterations depending on levels of improvement in those patients followed longitudinally. The main objective of this study was to describe the course of cognitive impairments in responder versus non-responder TRD patients at one-year follow-up. The second aim was to evaluate the predictive aspect of cognitive impairments to treatment resistance in patients suffering from TRD. We included 131 patients from a longitudinal cohort (FACE-DR) of the French Network of Expert TRD Centers. They undertook comprehensive sociodemographic, clinical, global functioning, and neuropsychological testing (TMT, Baddeley task, verbal fluencies, WAIS-4 subtests, D2 and RLRI-16) at baseline (V0) and one-year follow-up (V1). Most patients (n = 83; 63.36%) did not respond (47 women, 49.47 ± 12.64 years old), while one-third of patients responded (n = 48, 30 women, 54.06 ± 12.03 years old). We compared the cognitive performances of participants to average theoretical performances in the general population. In addition, we compared the cognitive performances of patients between V1 and V0 and responder versus non-responder patients at V1. We observed cognitive impairments during the episode and after a therapeutic response. Overall, each of them tended to show an increase in their cognitive scores. Improvement was more prominent in responders at V1 compared to their non-responder counterparts. They experienced a more marked improvement in code, digit span, arithmetic, similarities, and D2 tasks. Patients suffering from TRD have significant cognitive impairments that persist but alleviate after therapeutic response. Cognitive remediation should be proposed after therapeutic response to improve efficiency and increase the daily functioning. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20763425
Volume :
13
Issue :
7
Database :
Academic Search Index
Journal :
Brain Sciences (2076-3425)
Publication Type :
Academic Journal
Accession number :
168601066
Full Text :
https://doi.org/10.3390/brainsci13071120