A new chloro-azaphilone derivative with pro-angiogenesis activity from the hadal trench-derived fungus Chaetomium globosum YP-106.

A new chloro-azaphilone derivative chaetoviridin L (1) along with four known analogues, namely, chaetomugilin A (2), chaetoviridin E (3), chaetomugilin O (4), and chaephilone D (5), is isolated and identified from the culture extract of Chaetomium globosum YP-106, a deep-sea derived fungus obtained from the hadal zone seawater collected in the Yap Trench. Their structures were determined based on detailed interpretation of nuclear magnetic resonance (NMR) spectroscopic, mass spectrometry (MS) data analysis and comparison with the reported literature. The absolute configuration of the new compound was established by quantum chemical calculations of electronic circular dichroism (ECD). All the isolated compounds were evaluated for pro-angiogenesis activity using zebra fish model. Compounds 1, 2, and 5 significantly promoted the angiogenesis in a dose-dependent manner and thus, these compounds might be used as promising molecules for the treatment of cardiovascular disease. [ABSTRACT FROM AUTHOR]