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MicroRNAs: a developing story

Authors :
Pasquinelli, Amy E
Hunter, Shaun
Bracht, John
Source :
Current Opinion in Genetics & Development. Apr2005, Vol. 15 Issue 2, p200-205. 6p.
Publication Year :
2005

Abstract

Considering the intense genetic efforts applied to understanding development, it is surprising that a relatively large class of regulatory genes has newly surfaced. The first microRNA gene and its developmental role were described more than ten years ago, but only recently have we fully appreciated the broad and abundant presence of such genes. MicroRNAs are ∼22 nucleotide RNAs that use antisense complementarity to inhibit expression of specific mRNAs. Recent studies of restricted expression patterns and functional roles have implicated specific microRNAs in complex genetic pathways regulating embryogenesis, hematopoiesis, neuronal differentiation and Hox-mediated development. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
0959437X
Volume :
15
Issue :
2
Database :
Academic Search Index
Journal :
Current Opinion in Genetics & Development
Publication Type :
Academic Journal
Accession number :
16837495
Full Text :
https://doi.org/10.1016/j.gde.2005.01.002