Phosphorylated nuclear DICER1 promotes open chromatin state and lineage plasticity of AT2 tumor cells in lung adenocarcinomas.

The article focuses on a study conducted to analyze the impact of extracellular signal-regulated kinase (ERK) pathway phosphorylates DICER1 on lineage flexibility and open chromatin state of tumor cells in lung adenocarcinomas. The study reveals that murine AT2 tumor cells undergo altered chromatin compaction in advanced tumors, leading to the expression of gastric genes and transitioning from a restricted alveolar to a broader endodermal lineage state.