Palladium(II)-Catalyzed Intramolecular Tandem Cyclization Reaction for the Assembly of Unsymmetrical 2,6-Disubstituted Pyrazines.

C-N bond formation, C-C coupling, palladium catalysis, cascade reaction, 2,6-disubstituted pyrazines Likewise, dehydrogenative dimerization of 1,2-diols with NH SB 3 sb in the presence of Ru catalyst [15] gives rise to symmetrical 2,6-disubstituted pyrazines, albeit accompanied by a mixture of unsymmetrical 2,5-disubstituted pyrazines (Scheme 1 A). Keywords: C-C coupling; C-N bond formation; palladium catalysis; cascade reaction; 2,6-disubstituted pyrazines EN C-C coupling C-N bond formation palladium catalysis cascade reaction 2,6-disubstituted pyrazines 2554 2560 7 07/31/23 20230817 NES 230817 Graph Pyrazines are important N-heterocycles and occur ubiquitously in a wide variety of natural products, [1][2] bioactive agents, [3] agrochemicals, [4] and dyes. [Extracted from the article]