Dispersiones sólidas de solubilidad mejorada fabricadas en mezcladores de alto corte: una oportunidad para la industria farmacéutica local mexicana.

Introduction: Class II drugs represent a high percentage of the molecules in the biomedical research phase. This group has attracted research in recent years, since its low aqueous solubility conditions its absorption in vivo, which poses a challenge for pharmaceutical technology. Solid dispersion design (SD) is a technique that has been successful and is based on the dispersion of the drug in a polymeric carrier, promoting the amorphous state of the former. One of the methods of obtaining SD is melting, which can be carried out in sophisticated equipment, but high shear mixers (HSM) are also an alternative to obtain granules by melting. Aim: The objective of this work is to review if melt granulation processes have been reported using HSM for the manufacture of SD and to analyze the strengths, weaknesses, opportunities and threats of this equipment in said process. Method: In a documentary review methodology, 90 publications from the PubMed, ScienceDirect and Google Scholar databases from the last 20 years were pre-selected, of which eight describe the use of the fusion granulation method in HSM. Results: As results, it was seen that 100% of these cases reported higher solubility and dissolution speed than the pure drug. It is concluded that local companies that have HSM have the potential to launch successful SD manufacturing processes in HSM, with the advantage of not making an additional investment. [ABSTRACT FROM AUTHOR]