Comparative Study of the Effects of Addition of Intrathecal Fentanyl and Clonidine Added To 0.5% Hyperbaric Bupivacaine for Lower Segment Caesarean.

Background: To compare the analgesic activity of fentanyl and clonidine combined to Bupivacaine for caesarean section spinal anaesthesia. To compare hemodynamics, post-operative sedation, and newborn outcome. Material and Methods: 150 patients undergoing elective or emergency caesarean section were studied at Area Hospital, Dhone, Nandyal, Andhra Pradesh, India from October 2021 to September 2022. Randomly dividing patients into 3 groups of 50 each for injections. Physiological and demographic data, the start of analgesia, the peak of cephalic spread, the upper level of sensory block, and the grade of motor block were observed during surgery. The additional results' mean and SD were calculated. Statistical significance was determined using Anova tables. Results: Statistics showed that groups' greatest sensory levels were exceedingly highly significant (P 0.001). After five minutes in SBP, there were no significant differences between the three groups (P>0.05). At 15 minutes, group A considerably differed from groups B and C. (P 0.001). B&C, however, did not differ from one another significantly (P>0.05). At 30 minutes, A&B had a considerable difference (P 0.05). Sedation level 1 was associated to groups A and B. The second sedation level was tied to Group C. The aforementioned associations were statistically quite strong (P 0.001). Conclusion: Both intrathecal clonidine and the clonidine fentanyl combination improved the efficacy of intraoperative analgesia. Clonidine and fentanyl together significantly improved the intraoperative analgesic effects and sustained postoperative analgesia compared to clonidine alone. The operating room's hemodynamics were steady. Unexpectedly, the analgesia persisted longer. The medication's synergistic benefits virtually ever resulted in any side effects. The course of the developing foetus was unaltered. [ABSTRACT FROM AUTHOR]