STUDY OF SYSTEMIC IMMUNITY AND BACTERIOLOGICAL PROFILE OF SUBJECTS HAVING URINARY TRACT INFECTION IN INDIAN SUBJECTS.

Background: UTIs (urinary tract infections) are the most frequent bacterial disorder requiring medical management with a reported incidence of 8 million where nearly 20% need an emergency visit. Aim: The present study was done to study the systemic immunity and bacteriological profile of subjects having urinary tract infections in Indian subjects. The study focused on isolating the uropathogenic bacteria, assessing their antibiotic sensitivity, and evaluating the serum TLR2 levels in subjects with UTIs and healthy controls. Methods: In 200 blood and mid-stream urine study samples and 100 healthy samples of urine and blood as controls were subjected to TLR-2 detection. The samples from subjects with urinary tract infections were assessed for the presence of Uropathogenic bacteria (both grampositive and gram-negative). Results: The most common isolated bacteria were E. coli seen in 80% (n=160) study subjects followed by enterococcus faecalis in 50% (n=100) study subjects, Klebsiella pneumonia, enterococcus facium, and pseudomonas aeruginosa in 40% (n=80) subjects each, staphylococcus aureus in 36% (n=72) subjects. The mean TLR 2 level was significantly higher for cases subjects with urinary tract infections with a mean value of 3.875±1.495 compared to the control healthy subjects without urinary tract infections where the mean serum TLR2 value was 3.316±4.731. This difference was statistically significant with p=0.04 Conclusion: The present study concludes that subjects with active urinary tract infection commonly show more gram-negative bacteria than gram-positive bacteria with a predominance of E. coli, Klebsiella pneumonia, and staphylococcus spp. Also, toll-like receptor 2 is significantly higher in subjects with urinary tract infections compared to their control subjects. [ABSTRACT FROM AUTHOR]