药学服务对慢性阻塞性肺疾病患者噻托溴铵粉雾剂 使用正确率, 依从性和疗效的影响.

OBJECTIVE: To probe into the effects of pharmaceutical service on the correct use, compliance and efficacy of tiotropium bromide powder spray in patients with chronic obstructive pulmonary disease (COPD). METHODS: Totally 105 COPD patients admitted into the 983th Hospital of Joint Logistics Support Forces of PLA from Feb. 2018 to Aug. 2019 were selected as subjects, according to the order of admission and treatment, the patients were divided into two groups via random number table, 52 patients in control group did not receive any intervention, while the 53 patients in research group received pharmaceutical service intervention. The correct rate of use and compliance of tiotropium bromide powder spray were compared between two groups, the efficacy, pulmonary function and modified British medical research council (mMRC) rating were compared between two groups in 12-month follow-up visit. RESULTS:(1) At 6-month and 12-month follow-up visit, the correct rate of use, score of Morisky medication adherence scale-8 (MMAS-8), forced expiratory volume in 1 s (FEV1 ), the ratio of FEV1 and forced vital capacity (FVC) of research group were significantly higher those at 1 month of enrollment, and the mMRC ratings were significantly lower than that at 1 month of enrollment, with statistically significant differences (P < 0. 05). (2) At 12-month follow-up visit, the correct rate of tiotropium bromide powder spray use, MMAS-8 score, FEV1 and FEV1 / FVC of the research group were significantly higher than those at 6-month follow-up visit, and the mMRC rating was significantly lower than that at 6-month follow-up visit, with statistically significant differences (P < 0. 05). (3) At 6-month and 12-month follow-up visit, the correct rate of tiotropium bromide powder spray use, MMAS-8 score, FEV1 and FEV1 / FVC of the research group were significantly higher than those of the control group, and the mMRC rating was significantly lower than that of the control group, with statistically significant differences (P < 0. 05). (4) At 12-month follow-up visit, the overall effective rate of research group was significantly higher than that of the control group, with statistically significant differences (P < 0. 05). CONCLUSIONS: Pharmaceutical service can effectively promote the correct use, compliance and efficacy of tiotropium bromide powder spray in COPD patients, improve patients' pulmonary function and relieve dyspnea. [ABSTRACT FROM AUTHOR]