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Esophageal intraepithelial squamous cell neoplasia with epidermalization—A case with molecular analysis.
- Source :
-
Pathology International . Jul2023, Vol. 73 Issue 7, p327-329. 3p. - Publication Year :
- 2023
-
Abstract
- Although the carcinogenesis of SCC with EM is not understood,[5] EM is closely related to alcohol intake and tobacco smoking.[[1], [3], [5]] Then, we examined genetic characteristics using next-generation sequencing (NGS). Keywords: endoscopic submucosal dissection (ESD); epidermalization; epidermoid metaplasia; squamous cell carcinoma (SCC) EN endoscopic submucosal dissection (ESD) epidermalization epidermoid metaplasia squamous cell carcinoma (SCC) 327 329 3 07/27/23 20230701 NES 230701 Abbreviations CNV copy number variations ESD endoscopic submucosal dissection EM epidermoid metaplasia IPCL intra-papillary capillary vessels NGS next-generation sequencing SCC squamous cell carcinoma Epidermoid metaplasia (EM) is relatively common in the oral cavity, but rare in the esophagus.[1] It is defined by a well-developed granular layer and overlying hyperorthokeratosis close to the epidermis.[1] EM is principally benign, but is sometimes associated with dysplasia but seldom associated with carcinoma in and around the EM.[[2], [4]] We want to report a very rare case with esophageal squamous cell carcinoma (SCC) resembling EM and we analyzed molecular characteristics of this lesion. EM is characterized by a well-developed granular layer and overlying hyperorthokeratosis resembling the epidermis.[1] EM is essentially benign, but is seldom associated with SCC in and around the EM.[[2], [4]] Therefore, he underwent ESD and the resected whitish tumor measured 23 × 22 mm after formalin fixation. [Extracted from the article]
- Subjects :
- *DYSPLASIA
*TUMORS
*SQUAMOUS cell carcinoma
*HUMAN papillomavirus
Subjects
Details
- Language :
- English
- ISSN :
- 13205463
- Volume :
- 73
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Pathology International
- Publication Type :
- Academic Journal
- Accession number :
- 166735376
- Full Text :
- https://doi.org/10.1111/pin.13348