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Antibody-dependent cell-mediated cytotoxic responses in participants enrolled in a phase I/II ALVAC-HIV/AIDSVAX® B/E prime-boost HIV-1 vaccine trial in Thailand
- Source :
-
Vaccine . Mar2005, Vol. 23 Issue 19, p2522-2529. 8p. - Publication Year :
- 2005
-
Abstract
- Abstract: Antibody-dependent cell-mediated cytotoxicity (ADCC) was assessed in volunteers participating in an ALVAC-HIV (vCP1521)/AIDSVAX® B/E gp120 prime-boost vaccine trial in Thailand. ADCC activity was measured using chromium release from gp120 subtype B- and CRF01_AE-coated targets in 95 vaccinees and 28 placebo recipients. There was a significant difference in the magnitude of the ADCC response to both targets between vaccinees and placebo recipients. The frequency of responders to subtype B and to CRF01_AE was 96% and 84% in the vaccine group versus 11% and 7% in the placebo group. The results demonstrate that this HIV vaccine is a potent inducer of ADCC activity and may be an additional protection of this prime-boost vaccine in preventing HIV disease. [Copyright &y& Elsevier]
- Subjects :
- *IMMUNOGLOBULINS
*CELL-mediated cytotoxicity
*HIV infections
*VACCINES
Subjects
Details
- Language :
- English
- ISSN :
- 0264410X
- Volume :
- 23
- Issue :
- 19
- Database :
- Academic Search Index
- Journal :
- Vaccine
- Publication Type :
- Academic Journal
- Accession number :
- 16671355
- Full Text :
- https://doi.org/10.1016/j.vaccine.2004.10.028