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Familial aggregation of lung cancer in a high incidence area in China.

Authors :
Jin, Y. T.
Xu, Y. C.
Yang, R. D.
Huang, C. F.
Xu, C. W.
He, X. Z.
Source :
British Journal of Cancer. 4/11/2005, Vol. 92 Issue 7, p1321-1325. 5p.
Publication Year :
2005

Abstract

To investigate whether lung cancer clusters in families in a high incidence county of China, an analysis was conducted using data on domestic fuel history and tobacco use for family members of 740 deceased lung cancer probands and 740 controls (probands' spouses). Lung cancer prevalence was compared among first-degree relatives of probands and of controls, taking into account various factors using logistic regression and generalised estimating equations. First-degree relatives of probands, compared with those of controls, showed an excess risk of lung cancer (odds ratio (OR)=2.05, 95% confidence interval (CI): 1.68-2.53). Overall, female relatives of probands had a greater risk than did their male counterparts, and the risk was 2.90-fold for parents of probands as compared with parents of spouses. Female relatives of probands had 2.67-fold greater risk than female controls. Lung cancer risk was particularly marked among mothers (OR=3.78, 95% CI: 2.03-7.12). Having two or more affected relatives was associated with a 2.69-5.40-fold risk increase. The risk elevation was also found for other cancers overall. Results confirm previous findings of a genetic predisposition to lung cancer, and also imply that lung cancer may share a genetic background with other cancers. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00070920
Volume :
92
Issue :
7
Database :
Academic Search Index
Journal :
British Journal of Cancer
Publication Type :
Academic Journal
Accession number :
16635846
Full Text :
https://doi.org/10.1038/sj.bjc.6602465