Ultrasound-Guided HIFU Neurolysis Of Peripheral Nerves to Treat Spasticity and Pain.

Spasticity, a major complication of disorders of the central nervous system (CNS) signified by uncontrollable muscle contractions, is difficult to treat effectively. We report on the use of image-guided high-intensity focused ultrasound (HIFU) to target and suppress the function of the sciatic nerve complex of rabbits in vivo as a possible treatment of spasticity and pain. In situ focal acoustic intensity of 1480–1850 W/cm2 was applied using a scanning method. HIFU treatment of 36 ± 14 s (mean ± standard deviation) was effective in achieving complete conduction block in 100% of the 22 nerves treated (11 rabbits). Histological examination indicated axonal demyelination as a probable mechanism of nerve block. © 2005 American Institute of Physics [ABSTRACT FROM AUTHOR]