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Outcome of boost haemopoietic stem cell transplant for decreased donor chimerism or graft dysfunction in primary immunodeficiency.
- Source :
-
Bone Marrow Transplantation . Apr2005, Vol. 35 Issue 7, p683-689. 7p. - Publication Year :
- 2005
-
Abstract
- Summary:Haemopoietic stem cell transplants (HSCT) cure increasing numbers of primary immunodeficiencies (PID): residual recipient T-cell function increases risk of incomplete or decreasing immune reconstitution, which may resolve following a second, unconditioned, infusion from the same donor (boost infusion). We assessed the outcome of 20 boost infusions in 19/139 patients transplanted for PID patients at our centre since 1987. Boost infusion was given 64-1226 days after the original HSCT. Follow-up was 4-124 months. In all, 12 of 19 patients cleared viral infection (6), or showed sustained increase in donor chimerism, T- and B-cell numbers and function, or other markers (6). In 7/12 patients, immunoglobulin replacement has been discontinued. Four were partially successful with stable low-level chimerism (two patients) or improved T-cell function, but not B cell function (two patients). Four failed with no change in donor chimerism or cell number. No significant association with donor source, T-cell depletion, conditioning regimen, boost infusion stem cell dose or time from original HSCT to boost was found. One patient developed grade III acute graft-versus-host disease despite cyclosporine, and one developed severe pneumonitis; both have recovered. Boost infusion was successful or partially successful in 84%of patients. The risk of adverse effects is low.Bone Marrow Transplantation (2005) 35, 683-689. doi:10.1038/sj.bmt.1704872 Published online 21 February 2005 [ABSTRACT FROM AUTHOR]
- Subjects :
- *STEM cells
*VIRUS diseases
*B cells
*IMMUNOSUPPRESSIVE agents
*BONE marrow
*CELLS
Subjects
Details
- Language :
- English
- ISSN :
- 02683369
- Volume :
- 35
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Bone Marrow Transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 16506798
- Full Text :
- https://doi.org/10.1038/sj.bmt.1704872