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Purification, characterization and bioactivities of a 4-O-methylglucuronoxylan from Aralia echinocaulis.
- Source :
-
International Journal of Biological Macromolecules . Jul2023, Vol. 244, pN.PAG-N.PAG. 1p. - Publication Year :
- 2023
-
Abstract
- The discovery of active constituents from food plants is an important area of research in pharmaceutical sciences. Aralia echinocaulis is a medicinal food plant that is mainly used to prevent or treat rheumatoid arthritis in China. This paper reported the isolation, purification and bioactivity of a polysaccharide (HSM-1-1) from A. echinocaulis. Its structural features were analyzed according to the molecular weight distribution, monosaccharide composition, gas chromatography–mass spectrometry (GC–MS) and nuclear magnetic resonance spectra. The results indicated that HSM-1-1 was a new 4- O -methylglucuronoxylan mainly composed of xylan and 4- O -methyl glucuronic acid with the molecular weight of 1.6 × 104 Da. Furthermore, the antitumor and anti-inflammatory activities of HSM-1-1 in vitro were investigated, and the results showed that HSM-1-1 had potent proliferation inhibition activity on colon cancer cell SW480 with an inhibition rate of 17.57 ± 1.03 % at a concentration of 600 μg/mL, as measured via MTS methods. To our knowledge, this is the first report of a polysaccharide structure obtained from A. echinocaulis and its bioactivities, and its potential as an adjuvant natural product with antitumor effects is shown. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01418130
- Volume :
- 244
- Database :
- Academic Search Index
- Journal :
- International Journal of Biological Macromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 164867172
- Full Text :
- https://doi.org/10.1016/j.ijbiomac.2023.125402